Two HIV-positive young men—a semi-employed film critic and a hot hustler—tear off on a cross-country crime spree.

Vicky, an out-of-work actress, struggling waitress and lesbian has her whole life thrown into turmoil when her father comes from Germany to visit. The main problem is that Vicky has told him she is a successful actress and happily married. She enlists the help of a gay friend to play her husband. Using a large range of characters—gay, lesbian, straight, transsexuals—the film creates a funny and touching view of family dynamics and sexuality.

Buddy, a young gay man leaves his small-town home in rural Upstate New York to make a new life in New York City.